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KMID : 0903519920350050395
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1992 Volume.35 No. 5 p.395 ~ p.398
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Synthesis and biological activity of 6´ - phenylgriseofulvin as analogs of antibiotic griseofulvin
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Abstract
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In order to study the influence of a 6′-methyl group in ring C of griseofulvin (1＿) on the fungicidal activity, 6′-methyl group was replaced with a larger phenyl group as (±)-6′-phenylgriseofulvin (3＿), (±)-6′-epiphenylgriseofulvin (4＿), synthesized by a Diels-Alder cycloaddition. Their biological activities were examined against Botrytis allii (IFO 9430) and B. cinerea (AHU 9573). (±)-6′-Phenylgriseofulvin (3＿) showed high activity in 25 ㎍/disc.
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